Effect of drug lipophilicity and polar surface area on iontophoretic transdermal absorption.
نویسندگان
چکیده
منابع مشابه
Towards a Correlation between Polar Surface Area of Drugs with Ex-vivo Transdermal Flux Variability
The aim of the present study was to investigate the relationship between the polar surface area and other molecular properties of the model drugs and their transdermal permeability across the rat skin. Few model drugs which are weakly acidic (ibuprofen, aceclofenac and glipizide) and weakly basic (olanzapine, telmisartan and sildenafil citrate) were selected for the study based on Polar surface...
متن کاملA Comparative Study of Molecular Structure, pKa, Lipophilicity, Solubility, Absorption and Polar Surface Area of Some Antiplatelet Drugs.
Theoretical chemistry methods have been used to study the molecular properties of antiplatelet agents (ticlopidine, clopidogrel, prasugrel, elinogrel, ticagrelor and cangrelor) and several thiol-containing active metabolites. The geometries and energies of most stable conformers of these drugs have been computed at the Becke3LYP/6-311++G(d,p) level of density functional theory. Computed dissoci...
متن کاملIontophoretic transdermal drug delivery: a multi-layered approach.
We present a multi-layer mathematical model to describe the transdermal drug release from an iontophoretic system. The Nernst-Planck equation describes the basic convection-diffusion process, with the electric potential obtained by solving the Laplace's equation. These equations are complemented with suitable interface and boundary conditions in a multi-domain. The stability of the mathematical...
متن کاملtowards a correlation between polar surface area of drugs with ex-vivo transdermal flux variability
the aim of the present study was to investigate the relationship between the polar surface area and other molecular properties of the model drugs and their transdermal permeability across the rat skin. few model drugs which are weakly acidic (ibuprofen, aceclofenac and glipizide) and weakly basic (olanzapine, telmisartan and sildenafil citrate) were selected for the study based on polar surface...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 2001
ISSN: 1881-2732,0913-5006
DOI: 10.2745/dds.16.419